Prognostic significance of CD44 variant 2 upregulation in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Clinical significance of CD44 variants expression in colorectal cancer.
AIMS AND BACKGROUND We designed the present study to observe CD44s and CD44v6 expressions in colorectal cancer and evaluate their clinical value. METHODS CD44s and CD44v6 expression in colorectal cancer tissues were examined by an immunohistochemical test. Survival analysis was performed with the Kaplan-Meier method, and the differences between the CD44-positive and -negative groups were eval...
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Colorectal cancer stem cells are considered the source of recurrence, metastasis and drug resistance in colorectal tumors. Therefore, the identification and targeting of cancer stem cells facilitates the elimination of tumors. Although epithelial cell adhesion molecule-high (EpCAMhigh)/cluster of differentiation (CD)44+ cells are thought to act as a marker of colorectal cancer stem cells, the c...
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Background Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Currently, tumor-node-metastasis staging system still remains the gold standard for prognosis of CRC patients, but it is no longer sufficient. Among the most important molecules involved in colorectal tumor growth, cell proliferation and progression are adhesive molecules such as CD44 and E-cadherin (EC)....
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2014
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2014.253